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PUBLICATIONS

60. Simultaneous Stereoinvertive and Stereoselective C(sp³)–C(sp³)

Cross-Coupling of Boronic Esters and Allylic Carbonates

Hong-Cheng Shen, Ze-Shu Wang, Adam Noble and Varinder K. Aggarwal*

J. Am. Chem. Soc. 2024, DOI: 10.1021/jacs.4c03686 

Simultaneous Stereoinvertive and Stereoselective C(sp3)–C(sp3)  Cross-Coupling of Boronic Esters and Allylic Carbonates

59. Stereospecific Conversion of Boronic Esters into Enones using Methoxyallene: Application in the Total Synthesis of 10-Deoxymethynolide

Kristian J. Chambers, Patthadon Sanghong, Daniel Carter Martos, Giorgia Casoni, Rory C. Mykura, Durga Prasad Hari, Adam Noble and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 2023, 62, e202312054

Stereospecific Conversion of Boronic Esters into Enones using Methoxyallene: Application in the Total Synthesis of 10-Deoxymethynolide

58. Convergent Deboronative and Decarboxylative Phosphonylation Enabled by the Phosphite Radical Trap “BecaP”

Santosh K. Pagire, Chao Shu, Dominik Reich, Adam Noble*

and Varinder K. Aggarwal*

J. Am. Chem. Soc. 2023, 145, 18649–18657

Convergent Deboronative and Decarboxylative Phosphonylation Enabled by the Phosphite Radical Trap “BecaP”

57. Photoredox-Catalyzed Decarboxylative Bromination, Chlorination and Thiocyanation Using Inorganic Salts

Jingjing Wu, Chao Shu, Zhihang Li, Adam Noble*

and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 2023, 62e202309684

Photoredox-Catalyzed Decarboxylative Bromination, Chlorination and Thiocyanation Using Inorganic Salts

56. Iridium-Catalyzed Asymmetric Difunctionalization of C–C σ-Bonds Enabled by Ring-Strained Boronate Complexes

Hong-Cheng Shen, Mihai V. Popescu, Ze-Shu Wang, Louis de Lescure,

Adam Noble, Robert S. Paton* and Varinder K. Aggarwal*

J. Am. Chem. Soc. 2023145, 16508–16516

Iridium-Catalyzed Asymmetric Difunctionalization of C–C σ-Bonds Enabled by Ring-Strained Boronate Complexes

55. Copper-Mediated Dehydrogenative C(sp³)–H Borylation of Alkanes

Ruocheng Sang,  Wangyujing Han, Hanwen Zhang, Carla M. Saunders,

Adam Noble* and Varinder K. Aggarwal*

J. Am. Chem. Soc. 2023145, 15207–15217

Copper-Mediated Dehydrogenative C(sp³)–H Borylation of Alkanes

54. Synthesis of Dihydropyridine Spirocycles by Semi-Pinacol-Driven Dearomatization of Pyridines

Joseph C. Abell, Christian P. Bold, Laia Vicens, Tom Jentsch, Noelia Velasco, Jasper L. Tyler, Robert N. Straker, Adam Noble and Varinder K. Aggarwal*

Org. Lett. 202325, 400–404

Synthesis of Dihydropyridine Spirocycles by Semi-Pinacol-Driven Dearomatization of Pyridines

53. Strain-Release Driven Epoxidation and Aziridination of

Bicyclo[1.1.0]butanes via Palladium Catalyzed σ-Bond Nucleopalladation

Bernhard Wölfl, Nils Winter, Jiajing Li, Adam Noble

and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 202362, e202217064

Strain-Release Driven Epoxidation and Aziridination of  Bicyclo[1.1.0]butanes via Palladium Catalyzed σ-Bond Nucleopalladation

52. Iterative Synthesis of 1,3-Polyboronic Esters with High Stereocontrol and Application to the Synthesis of Bahamaolide A

Sheenagh G. Aiken, Joseph M. Bateman, Hsuan-Hung Liao, Alexander Fawcett, Teerawut Bootwicha, Paolo Vincetti, Eddie L. Myers, Adam Noble

and Varinder K. Aggarwal*

Nat. Chem. 2023, 15, 248–256

Iterative Synthesis of 1,3-Polyboronic Esters with High Stereocontrol and Application to the Synthesis of Bahamaolide A

51. Automated Stereocontrolled Assembly-Line Synthesis of Organic Molecules

Valerio Fasano, Rory C. Mykura, James M. Fordham, Jack J. Rogers, Borys Banecki, Adam Noble and Varinder K. Aggarwal*

Nat. Synth. 2022, 1, 902907

Automated Stereocontrolled Assembly-Line Synthesis of Organic Molecules

50. Four-Component Strain-Release-Driven Synthesis of Functionalized Azetidines

Jasper L. Tyler, Adam Noble and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 202261, e202214049

Four-Component Strain-Release-Driven Synthesis of Functionalized Azetidines

49. Facile Conversion of α-Amino Acids into α-Amino Phosphonates by Decarboxylative Phosphorylation using Visible-Light Photocatalysis

Dominik Reich, Adam Noble and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 202261, e202207063

Facile Conversion of α-Amino Acids into α-Amino Phosphonates by Decarboxylative Phosphorylation using Visible-Light Photocatalysis

48. Dual Nickel/Photoredox-Catalyzed Site-Selective Cross-Coupling of 1,2-Bis-Boronic Esters Enabled by 1,2-Boron Shifts

Hui Wang, Wangyujing Han, Adam Noble and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 202261, e202207988

Dual Nickel/Photoredox-Catalyzed Site-Selective Cross-Coupling of 1,2-Bis-Boronic Esters Enabled by 1,2-Boron Shifts

47. Diastereodivergent Synthesis of Cyclopentyl Boronic Esters Bearing Contiguous Fully Substituted Stereocenters

Molly E. Fairchild, Adam Noble and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 202261, e202205816

Diastereodivergent Synthesis of Cyclopentyl Boronic Esters Bearing Contiguous Fully Substituted Stereocenters

46. Stereocontrolled Total Synthesis of Bastimolide B Using Iterative Homologation of Boronic Esters

Daniele Fiorito, Selbi Keskin, Joseph M. Bateman, Malcolm George,

Adam Noble, and Varinder K. Aggarwal*

J. Am. Chem. Soc. 2022, 144, 7995–8001

Stereocontrolled Total Synthesis of Bastimolide B Using Iterative Homologation of Boronic Esters

45. Selective Coupling of 1,2-Bis-Boronic Esters at the more Substituted Site through Visibile-Light Activation of Electron Donor-Acceptor Complexes

Hui Wang, Jingjing Wu, Adam Noble and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 202261, e202202061

Selective Coupling of 1,2-Bis-Boronic Esters at the more Substituted Site through Visibile-Light Activation of Electron Donor-Acceptor Complexes

44. Sequential Photocatalytic Reactions for the Diastereoselective Synthesis of Cyclobutane Scaffolds

Mark J. Deeprose, Martin Lowe, Adam Noble*, Kevin I. Booker-Milburn*

and Varinder K. Aggarwal*


Org. Lett. 2022, 24, 137–141

Sequential Photocatalytic Reactions for the Diastereoselective Synthesis of Cyclobutane Scaffolds

43. Strain-Release-Driven Friedel-Crafts Spirocyclization of Azabicyclo[1.1.0]butanes

Jasper L. Tyler, Adam Noble and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 2022, 61, e202114235

Strain-Release-Driven Friedel-Crafts Spirocyclization of Azabicyclo[1.1.0]butanes

42. Direct Observation of Reactive Intermediates by Time-Resolved Spectroscopy Unravels the Mechanism of a Radical-Induced

1,2-Metalate Rearrangement

Luke Lewis-Borrell, Mahima Sneha, Ian P. Clark, Valerio Fasano,

Adam Noble, Varinder K. Aggarwal* and Andrew J. Orr-Ewing*

J. Am. Chem. Soc. 2021, 143, 17191–17199

Direct Observation of Reactive Intermediates by Time-Resolved Spectroscopy Unravels the Mechanism of a Radical-Induced  1,2-Metalate Rearrangement

41. Chiral Benzothiophene Synthesis via Enantiospecific Coupling of Benzothiophene S-Oxides with Boronic Esters

Ruocheng Sang, Adam Noble and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 2021, 60, 25313–25317

Chiral Benzothiophene Synthesis via Enantiospecific Coupling of Benzothiophene S-Oxides with Boronic Esters

40. Diastereoselective Photoredox-Catalyzed [3 + 2] Cycloadditions

of N-Sulfonyl Cyclopropylamines with Electron-Deficient Olefins

Dawn H. White, Adam Noble, Kevin I. Booker-Milburn*

and Varinder K. Aggarwal*


Org. Lett. 2021, 23, 3038–3042

Diastereoselective Photoredox-Catalyzed [3 + 2] Cycloadditions  of N-Sulfonyl Cyclopropylamines with Electron-Deficient Olefins

39. Strain-Release Driven Spirocyclization of Azabicyclo[1.1.0]butyl

Ketones

Jasper L. Tyler, Adam Noble and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 2021, 60, 11824–11829

Strain-Release Driven Spirocyclization of Azabicyclo[1.1.0]butyl  Ketones

38. Divergent, Strain-Release Reactions of Azabicyclo[1.1.0]butyl

Carbinols: Semipinacol or Spiroepoxy Azetidine Formation

Charlotte H. U. Gregson, Adam Noble and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 2021, 60, 7360–7365

Divergent, Strain-Release Reactions of Azabicyclo[1.1.0]butyl  Carbinols: Semipinacol or Spiroepoxy Azetidine Formation

37. Metal-Free Photoinduced C(sp³)–H Borylation of Alkanes

Chao Shu, Adam Noble* and Varinder K. Aggarwal*

Nature 2020, 586, 714–719

Metal-Free Photoinduced C(sp³)–H Borylation of Alkanes

36. α-Selective Ring Opening Reactions of Bicyclo[1.1.0]butyl

Boronic Ester with Nucleophiles

Lin Guo, Adam Noble and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 2021, 60, 212–216

α-Selective Ring Opening Reactions of Bicyclo[1.1.0]butyl  Boronic Ester with Nucleophiles

35. Photoinduced Fragmentation Borylation of Cyclic Alcohols

and Hemiacetals

Chao Shu, Rudrakshula Madhavachary, Adam Noble* and Varinder K. Aggarwal*


Org. Lett. 2020, 22, 7213–7218

Photoinduced Fragmentation Borylation of Cyclic Alcohols  and Hemiacetals

34. Iridium-Catalyzed Enantioselective Synthesis of Chiral

Bicyclo[1.1.1]pentanes by 1,3-Difunctionalization of [1.1.1]Propellane

Songjie Yu, Changcheng Jing, Adam Noble and Varinder K. Aggarwal*

Org. Lett. 2020, 22, 5650–5655

Iridium-Catalyzed Enantioselective Synthesis of Chiral  Bicyclo[1.1.1]pentanes by 1,3-Difunctionalization of [1.1.1]Propellane

33. Stereospecific 1,2-Migrations of Boronate Complexes Induced by Electrophiles (review)

Hui Wang, Changcheng Jing, Adam Noble and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 2020, 59, 16859–16872

Stereospecific 1,2-Migrations of Boronate Complexes Induced by Electrophiles

32. Divergent, Stereospecific Mono- and Difluoromethylation of

Boronic Esters 

Valerio Fasano, Nils Winter, Adam Noble and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 2020, 59, 8502–8506

Divergent, Stereospecific Mono- and Difluoromethylation of  Boronic Esters

31. Visible Light-Driven Strain-Increase Ring Contraction Allows the Synthesis of Cyclobutyl Boronic Esters 

Raffael Davenport, Mattia Silvi, Adam Noble, Zied Hosni, Natalie Fey

and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 2020, 59, 6525–6528

Visible Light-Driven Strain-Increase Ring Contraction Allows the Synthesis of Cyclobutyl Boronic Esters

30. Decarboxylative Conjunctive Cross-coupling of Vinyl Boronic Esters using Metallaphotoredox Catalysis  

Riccardo S. Mega, Vincent K. Duong, Adam Noble* and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 2020, 59, 4375–4379

Decarboxylative Conjunctive Cross-coupling of Vinyl Boronic Esters using Metallaphotoredox Catalysis

29. 1,3-Difunctionalizations of [1.1.1]Propellane via 1,2-Metallate Rearrangements of Boronate Complexes 

Songjie Yu, Changcheng Jing, Adam Noble and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 2020, 59, 3917–3921

1,3-Difunctionalizations of [1.1.1]Propellane via 1,2-Metallate Rearrangements of Boronate Complexes

28. Ring-Opening Lithiation–Borylation of 2-Trifluoromethyl Oxirane: A Route to Versatile Tertiary Trifluoromethyl Boronic Esters 

Meganathan Nandakumar, Belén Rubial, Adam Noble,

Eddie L. Myers* and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 2020, 59, 1187–1191

Ring-Opening Lithiation–Borylation of 2-Trifluoromethyl Oxirane: A Route to Versatile Tertiary Trifluoromethyl Boronic Esters 

27. Methylenespiro[2.3]hexanes via Nickel-Catalyzed Cyclopropanations with [1.1.1]Propellane 

Songjie Yu, Adam Noble, Robin B. Bedford*, and Varinder K. Aggarwal*

J. Am. Chem. Soc. 2019, 141, 20325–20334

Methylenespiro[2.3]hexanes via Nickel-Catalyzed Cyclopropanations with [1.1.1]Propellane

26. Photoinduced Deoxygenative Borylations of Aliphatic Alcohols

Jingjing Wu, Robin Bär, Lin Guo, Adam Noble and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 2019, 58, 18830–18834

Photoinduced Deoxygenative Borylations of Aliphatic Alcohols

25. 1,2-Boron Shifts of β-Boryl Radicals Generated from Bis-boronic Esters Using Photoredox Catalysis

Daniel Kaiser, Adam Noble, Valerio Fasano, and Varinder K. Aggarwal*

J. Am. Chem. Soc. 2019, 141, 14104–14109

1,2-Boron Shifts of β-Boryl Radicals Generated from Bis-boronic Esters Using Photoredox Catalysis

24. Triphenylphosphine and Sodium Iodide: A New Catalyst Combination to Rival Precious Metal Complexes in Visible Light Photoredox Catalysis (highlight)

Adam Noble and Varinder K. Aggarwal*

Sci. China Chem. 2019, 62, 1083–1084

Triphenylphosphine and Sodium Iodide: A New Catalyst Combination to Rival Precious Metal Complexes in Visible Light Photoredox Catalysis

23. Catalyst-Free Deaminative Functionalizations of Primary Amines via Photoinduced Single-Electron Transfer

Jingjing Wu, Phillip S. Grant, Xiabing Li, Adam Noble 

and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 2019, 58, 5697–5701

Catalyst-Free Deaminative Functionalizations of Primary Amines via Photoinduced Single-Electron Transfer

22. Photoredox-Catalyzed Cyclobutane Synthesis via a Deboronative Radical Addition–Polar Cyclization Cascade

Chao Shu, Adam Noble and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 2019, 58, 1366–1370

Photoredox-Catalyzed Cyclobutane Synthesis via a Deboronative Radical Addition–Polar Cyclization Cascade
Enantiospecific Synthesis of ortho-Substituted 1,1-Diarylalkanes by a 1,2-Metalate Rearrangement/anti-SN2' Elimination/Rearomatizing Allylic Suzuki-Miyaura Reaction Sequence

21. Enantiospecific Synthesis of ortho-Substituted 1,1-Diarylalkanes by a 1,2-Metalate Rearrangement/anti-S   2' Elimination/Rearomatizing Allylic Suzuki-Miyaura Reaction Sequence

Belén Rubial, Beatrice S. L. Collins, Raphael Bigler, Stefan Aichhorn,

Adam Noble and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 2019, 58, 1366–1370

N

20. Complex Boron-Containing Molecules through a 1,2-Metalate Rearrangement/anti-S   2' Elimination/Cycloaddition Reaction Sequence

Chloe Tillin, Raphael Bigler, Renata Calo-Lapido, Beatrice S. L. Collins,

Adam Noble and Varinder K. Aggarwal*

Synlett 201930, 449­–453

N

Complex Boron-Containing Molecules through a 1,2-Metalate Rearrangement/anti-SN2' Elimination/Cycloaddition Reaction Sequence

19. Chiral Aniline Synthesis via Stereospecific C(sp³)–C(sp²) Coupling of Boronic Esters with Aryl Hydrazines

Venkataraman Ganesh, Adam Noble and Varinder K. Aggarwal*

Org. Lett. 201820, 6144–6147

Chiral Aniline Synthesis via Stereospecific C(sp³)–C(sp²) Coupling of Boronic Esters with Aryl Hydrazines

18. Synthesis of Functionalized Cyclopropanes from Carboxylic Acids via a Radical Addition–Polar Cyclization Cascade

Chao Shu, Riccardo S. Mega, Björn J. Andreassen, Adam Noble* and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 2018, 57, 15430–15434

Synthesis of Functionalized Cyclopropanes from Carboxylic Acids via a Radical Addition–Polar Cyclization Cascade

17. Photoinduced Deaminative Borylation of Alkylamines

Jingjing Wu, Lin He, Adam Noble and Varinder K. Aggarwal*

J. Am. Chem. Soc. 2018, 14010700–10704

Photoinduced Deaminative Borylation of Alkylamines

16. Enantiodivergent Synthesis of Allenes by Point to Axial Chirality Transfer

Roly J. Armstrong, Meganathan Nandakumar, Rafael M. P. Dias,

Adam Noble, Eddie L. Myers and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 2018, 57, 8203–8208

Enantiodivergent Synthesis of Allenes by Point to Axial Chirality Transfer

15. Stereo- and Regiocontrolled Methylboration of Terminal Alkynes

Oleksandr Zhurakovskyi, Rafael M. P. Dias, Adam Noble

and Varinder K. Aggarwal*

Org. Lett. 2018, 20, 3136–3139

Stereo- and Regiocontrolled Methylboration of Terminal Alkynes

14. Enantiospecific Three-Component Alkylation of Furan and Indole

Mattia Silvi, Raffael Schrof, Adam Noble and Varinder K. Aggarwal*

Chem. Eur. J. 2018, 24, 4279–4282

Enantiospecific Three-Component Alkylation of Furan and Indole

13. Enantiospecific sp²–sp³ Coupling of o- and p-Phenols with Secondary and Tertiary Boronic Esters

Claire M. Wilson, Venkataraman Ganesh, Adam Noble and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 2017, 56, 16318–16322

nantiospecific sp2–sp3 Coupling of o- and p-Phenols with Secondary and Tertiary Boronic Esters

Postdoc, PhD, and Undergraduate

12. Visible-Light-Mediated Decarboxylative Radical Additions to Vinyl Boronic Esters: Rapid Access to γ-Amino Boronic Esters

Adam Noble, Riccardo S. Mega, Daniel Pflästerer, Eddie L. Myers and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 201857, 2155–2159

Visible-Light-Mediated Decarboxylative Radical Additions to Vinyl Boronic Esters: Rapid Access to γ-Amino Boronic Esters

11. Enantiospecific Trifluoromethyl-Radical-Induced Three-Component Coupling of Boronic Esters with Furans

Yahui Wang, Adam Noble, Christopher Sandford

and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 2017, 56, 1810–1814

Enantiospecific Trifluoromethyl-Radical-Induced Three-Component Coupling of Boronic Esters with Furans

10. Short, Enantioselective Total Synthesis of Tatanan A

Through an Assembly-Line Synthesis Approach

Adam Noble, Stefan Roesner and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 2016, 55, 15920–15924

Short, Enantioselective Total Synthesis of Tatanan A  Through an Assembly-Line Synthesis Approach

9. Enantiospecific Alkynylation of Alkylboronic Esters

Yahui Wang, Adam Noble, Eddie L. Myers and Varinder K. Aggarwal*

Angew. Chem. Int. Ed. 2016, 55, 4270–4274

Enantiospecific Alkynylation of Alkylboronic Esters

8. Palladium-Catalyzed Reactions of Allylic Boronic Esters with Nucleophiles: Novel Umpolung Reactivity

Phillip J. Unsworth, Lonrenz E. Löffler, Adam Noble and Varinder K. Aggarwal*

Synlett 2015, 26, 1567–1572

Palladium-Catalyzed Reactions of Allylic Boronic Esters with Nucleophiles: Novel Umpolung Reactivity

7. Merging Photoredox and Nickel Catalysis: Decarboxylative

Cross-Coupling of Carboxylic Acids with Vinyl Halides

Adam Noble, Stefan J. McCarver and David W. C. MacMillan*

J. Am. Chem. Soc. 2015, 137, 624–627

Merging Photoredox and Nickel Catalysis: Decarboxylative  Cross-Coupling of Carboxylic Acids with Vinyl Halides

6. Photoredox α-Vinylation of α-Amino Acids and N-Aryl Amines

Adam Noble and David W. C. MacMillan*

J. Am. Chem. Soc. 2014, 136, 11602–11605

Photoredox α-Vinylation of α-Amino Acids and N-Aryl Amines

5. Nitro-Mannich Reaction (review)

Adam Noble and James C. Anderson*

Chem. Rev. 2013, 113, 2887–2939

Nitro-Mannich Reaction

4. An Intramolecular Nitro-Mannich Route to Functionalised Tetrahydroquinolines

James. C. Anderson*, Adam Noble, and Pascual Ribelles Torres

Tetrahedron Lett. 2012, 53, 5707–5710

An Intramolecular Nitro-Mannich Route to Functionalised Tetrahydroquinolines

3. Reductive Nitro-Mannich Route for the Synthesis of 1,2-Diamine Containing Indolines and Tetrahydroquinolines

James. C. Anderson*, Adam Noble and Derek A. Tocher

J. Org. Chem. 2012, 77, 6703–6727

Reductive Nitro-Mannich Route for the Synthesis of 1,2-Diamine Containing Indolines and Tetrahydroquinolines

2. NMR Chemical Shifts of Molecules Encapsulated in Single Walled Carbon Nanotubes

Nicholas A. Besley* and Adam Noble

J. Chem. Phys. 2008, 128, 101102

1. Time-Dependent Density Functional Theory Study of the X-ray Absorption Spectroscopy of Acetylene, Ethylene and Benzene on Si(100)

Nicholas A. Besley* and Adam Noble

J. Phys. Chem. C 2007, 111, 3333–3340

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